All hormone therapy is not the same. If a woman has had a hysterectomy (removal of
the uterus) and wants to go on hormone therapy, she only needs estrogen. If she has a uterus, she will usually take
both estrogen and progesterone therapy.
If a woman has a uterus and is on estrogen without progesterone, she will increase her risk for uterine cancer.
There are substantial differences in risk of breast cancer whether a woman is on estrogen
alone or estrogen and progesterone. According to the Women’s Health Initiative Study, women who take only
estrogen appear to have no increased risk for breast cancer (2006). Only women taking both estrogen and
progesterone have a slight increase risk in breast cancer.
There are also differences in cholesterol changes in women on estrogen versus estrogen plus
progesterone. Women taking estrogen and progesterone can experience an increase in their cholesterol levels that may
increase risk for heart disease. On the other hand, women on estrogen alone do not experience similar cholesterol changes.
Estrogen is the component of hormone replacement that decreases the side effects of menopause
such as hot flashes, vaginal dryness, insomnia, etc. Progesterone is added to estrogen therapy in
women with a uterus to prevent uterine cancer. If estrogen is given alone, the uterus may respond with overgrowth of
the uterine lining creating an environment where cancer will start.
Estrogens come n many forms. Some come from animal
sources, some from plant sources, and some from direct manufacturing. All are available by prescription and in
multiple dosages. Women and their octors should attempt to decrease estrogen dosages as low as possible but
still control menopausal symptoms. Many omen will be able to wean off the medications if done slowly. Many other women will never be comfortable
without the use of estrogen. This is a ecision you and your doctor will make over time.
Progesterone is hormone used in menopause solely to prevent uterine cancer in women taking
estrogen for menopausal symptoms. For ealthy menopausal women, progesterone has no other benefits or indications for
use. In fact, because the addition of progesterone to estrogen in the menopause increases risk for breast cancer and
increases cholesterol, there may be health risks to its use. Progesterone comes in two main products. One is the synthetic Provera and the second
is a more natural product Prometrium. Both are sufficient to prevent uterine cancer.